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Mechanistic Compatibility Matrix Compatible combinations Different biological lanes: Appetite regulation + peripheral lipolysis Metabolic regulation + tissue repair Weight loss therapy + muscle preservation strategy Potentially redundant combinations Same biological pathway: GLP-1 + GLP-1 mimetic Multiple fat-loss peptides targeting identical signaling Multiple GH secretagogues Redundant stacks increase risk without improving outcomes

3.2 Different GLP-1 RA-related signals Three GLP-1 RAs displayed positive SOC signals in Table 2: semaglutide (ROR, 3.34

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